Special Issue on the segmental progeria Cockayne syndrome

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Hutchinson-Gilford Progeria Syndrome

The Hutchinson-Gilford syndrome or progeria is a laminopathy generated by mutations that affect LMNA gene. This produces an abnormal protein named progerine which alters the formation of the cellular membrane inducing premature aging of all cells. In the present review aspects related to the pathophysiology and clinical characteristics of this syndrome are shown.

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ژورنال

عنوان ژورنال: Mechanisms of Ageing and Development

سال: 2013

ISSN: 0047-6374

DOI: 10.1016/j.mad.2013.04.002